1D-LSD - The Ultimate Guide

It seems there is an endless game of NPS laws written to suppress the structures of lysergamides, then met by yet another design that circumvents those laws. With 1D-LSD, we begin to see how exotic that design can become - a brilliant structure that suggests that the LSD prodrug design series cannot ever be contained, and that just about any imaginable substitutions can still provide active molecules.

1D-LSD is short for 1-Dimethylcyclobutanoyl-LSD. The naming convention is the same for the series of 1-substituted LSD analogues that share a similar pharmacokinetic profile - where we see such compounds as 1P, 1cP, 1B, or 1V- LSD. All of these molecules have a structure called a carbonyl group attached to the 1-position of the LSD molecule, this position being a nitrogen atom that forms a structure reminiscent of the tryptamine molecule within the LSD molecule.

The carbonyl group is a carbon bonded to an oxygen with any variation of carbon atoms proceeding after it. In 1P-LSD, this is a propanoyl group: three carbons and an oxygen; in 1V-LSD it is a five carbon valeroyl group. These are simple chains of carbons, all are known to be active, and logical molecular design suggests that you can get similar effects by just continually extending that special carbon chain. 1D-LSD is a radical design that places an uncommon ring structure, the dimethylcyclobutanoyl group, in that position. And despite this being so far removed from those tried and true simple carbon chains, it is still remarkably active - and not just active but quite potent!

​

​

1D-LSD shares many similarities with its cousin molecules, but has some interesting modifications that we will explore here. For example - what is the significance of the 1-carbonyl substitution on the LSD molecule? Well, first we must learn the idea of a prodrug- A prodrug is a molecule that may not be an active substance in its own right, but the human body will consistently metabolize it into another active drug, that then goes on to exhibit effects on the mind and body.

It has been demonstrated that any 1-carbonyl substitution on the LSD molecule simply serves as a prodrug to LSD. In other words, upon ingestion of the 1-substituted LSD analogue, your body will convert the molecule to LSD, which will then enter your brain. An interesting phenomenon has been observed from this- on paper these 1-substituted LSD analogues should all yield a fairly standard LSD experience, but many users report a distinct character to each different compound.

Is this just the power of suggestion, and differences in set and setting, or is there some other quality of these molecules that lends them each a unique experience, even though the end result in the body is the same? There is as of yet no consensus, and that is for the individual user to discover! But for now, there is another such molecule on the scene for us to enjoy: 1D-LSD!

It should be noted that while these 1-substitution variations on the molecule do not seem to affect the neurological action much, the physical metabolic effects can lead to an array of changes in potency and duration between them. 1D-LSD appears to be the most potent of this series so far.

​

​

Flavour: While the old adage is that if a tab is bitter, it is likely some sort of non-lysergamide research chemical, 1D-LSD has the unique distinction of actually being a lysergamide with a bitter flavour! So long as the tabs are properly labelled from a trusted source, this is no cause for alarm!

Dosage: The standard marketed dose of 150 µg 1D-LSD has proven to be quite intense, and we suggest that users start lower than that (though more experienced users have taken much higher doses without issue). 1D-LSD is by far the most potent of the 1-substituted lysergamides, nearing in potency to LSD itself (and it turns out most LSD people encounter is dosed much lower than what they are told). Caution should be exercised when exploring this one- I and others found the standard 150 µg dose to be quite intense, and it may be a bit much for beginners.

Duration: 1D-LSD has a standard long duration like many lysergamides, with an onset of about 30 minutes. A long, drawn-out peak can last anywhere from 6-8 hours, with the comedown bringing the total duration to about 10-13 hours.

In terms of subjective effects, as another prodrug to LSD, the effects from 1D-LSD can be expected to be very similar. Certain themes can be pulled from a few of the existing reports on the compound:

• Music Appreciation: Several users reported profound music appreciation.

I went out into the kitchen and had my stereo as loud as it could go. I started crying tears of joy as the guitar solo was magnificent. As I was wiping the tears from my eyes, I looked out my front window and saw my neighbour walking her dog, she had stopped in front of my house and was enjoying the same solo as I was, or at least that is what I told myself.”While Mario W reported:“I will now put on some music and see where the ride gets me. Like all the other LSD analogues, music is greatly enhanced and overall a very pleasant experience.

• Synesthesia: in hand with the music appreciation, other users reported profound synesthesia.

While listening to Third - Hiatus, I probably had the most amazing synaesthetic experience ever. I could basically see the music floating in my room right before me and it was beyond beautiful. Like a 3D Windows media player visualization but 3000 times more amazing. This music was just made to be listened to on acid, no doubt about that. Every single drop burnt right into my deepest inner self, while those fine lines of music were floating right above me. I could feel and see every nuance, every delayed drop and fade-off. After that I listened to Gajumara from Yaima and holy shit, this hit deep. When the singer started to sing, her face appeared right above me, while her voice was floating as a fine line around. I listened to the lyrics and that hit deep.

• Visual Effects: While visual effects can vary widely between individuals, several users report “wavy” visuals.

Coming up really hard right now, big body load, euphoria and some wavy optics start to happen.

There wasn’t a single straight line in my vision, but I was still pretty in control of my surroundings. Except managing my hi-fi-system proved to be a little challenging.

• Euphoria: Many users report a fantastic euphoric experience.

Mario W Reports:

I'm in a good mood and very euphoric! I'd say my headspace is pretty tame, I can think relatively straight.

General feeling is much more euphoric than other analogues, but maybe I just had a euphoric day, will need to try again to confirm. Thinking about old vs. new music.

• Insight/Introspection: Many users report introspection with this compound, leading them to profound thoughts and new insights.

Thinking about a lot of stuff, thinking about work too. Thinking about my friends and why most of them just like to sit at home and do nothing… I realise how much I procrastinate on everything and thinking of getting this long overdue ADHD assessment done, that I have been procrastinating on for a long while lol. Do a bit of mindfulness.

• Nausea: Several reporters including myself mentioned a higher degree of nausea relative to other lysergamides from this experience. This can be mitigated through anti-nausea medications, or by chewing fresh ginger root or consuming a beverage with real ginger juice.

My 1D-LSD trip report

Closing thoughts from Nervewing

Legality and Availability