Introduction
The One-On, One-Off Protocol

What is One-On, One-Off Microdosing?
One of the most popular and straightforward microdosing methods is the one day on, one day off protocol.
Known as the “one-on, one-off” protocol, it is a straightforward approach where you take a microdose on one day and then abstain from microdosing on the following day. This cycle then repeats. One on, one off, one on, one off and so on. Simple.
This method provides a balance between experiencing potential benefits and allowing your body a day of rest to potentially avoid rapid tolerance build-up.
Its simplicity and potential for consistent effects have made it a preferred choice for many people exploring microdosing.
Benefits and Drawbacks
The one day on, one day off microdosing protocol offers a couple of benefits. Firstly, its simplicity makes it an ideal choice for beginners. The ease of remembering the schedule reduces the risk of confusion or missed doses. Secondly, consistency can prove to be key for experiencing benefits in microdosing, and this protocol allows you to establish a regular routine, which may lead to more consistent effects.
However, this approach also has a couple of drawbacks. Compared to protocols with longer breaks between doses, the one day on, one day off approach might lead to tolerance building up more quickly. This could mean there is a need for taking breaks or adjusting the dosage over time.
Whilst the one-on one-off approach has an inherent simplicity to it, it is also important to note that dosing days will fall on different days of the week each week. For example, if starting on a Monday, week one’s microdose days would be Monday, Wednesday, Friday, and Sunday. Week two would then see microdose days fall on Tuesday, Thursday, and Saturday. This can make tracking your microdosing schedule more challenging, especially compared to protocols like the Stamets Stack, which maintains a consistent dosing pattern that fits within the timespan of a week.
Adjusting to the Weekly Schedule
To combine the consistency of doses offered by this approach with a pattern that fits within the timespan of a week, it is possible to make a simple and slight alteration so that microdosing days are on the same days each week. To do this all you need to do is take a two day break each week (in place of a one day break) and it will fall into a seven day structure.
For example, designate microdose days to Monday, Wednesday, and Friday. Saturday and Sunday are then the two days off and the cycle begins again on Monday.
Alternatively, you might have microdosing days Tuesday, Thursday, and Saturday.
By maintaining a consistent dosing frequency of three days per week, this variation has a consistency that falls between the Fadiman Protocol (2-3 days per week) and the Stamets Stack (4-5 days per week). This means that it will have a balance of the benefits of consistent microdosing as well as an easy to follow structure.
Cycle Duration and Breaks
Similar to the Fadiman and Stamets protocols, it is recommended to consider taking breaks from this cycle every few months. Breaks are recommended to be approximately two to four weeks. This can help prevent tolerance build-up and allow your body to reset. Additionally, if you experience any adverse effects, it is important to discontinue microdosing and consult with a healthcare professional.
Who is it for? Ideal Candidates for One-on One-off
The one-on, one-off microdosing protocol is well-suited for people who want simplicity and consistency. It can be a good starting point for those new to microdosing, or people with busy schedules, as it requires minimal planning and tracking.
Intuitive Microdosing

While structured protocols like one-on one-off, Fadiman, and the Stamets Stack offer a clear framework for microdosing, some individuals prefer a more flexible approach. Intuitive microdosing offers such an approach.
What is Intuitive Microdosing?
Intuitive microdosing is a flexible and self-guided approach that abandons any fixed schedule.
Instead of adhering to a predetermined pattern, microdosers make decisions about when to dose based on their intuition and immediate needs considering factors such as energy levels, mood, and external circumstances such as environment, schedule and planned activities.
In its essence, intuitive microdosing means no fixed pattern to dosing, with the decision of whether or not to microdose on any particular day being made on that day. This approach emphasises personal judgement and responsiveness to internal cues.
Dosage Variations
An intuitive approach might also mean that the precise dose of the microdose itself is not fixed. While some people may have a set standard microdose, such as 0.1 grams of dried mushrooms, intuitive microdosers who have a lot of experience and know how slight variations affect them, may slide up and down, depending on the day. For example, if they are planning a day hiking out in nature, they may slide it up to 0.2 grams finding that the slightly higher microdose helps them slow down and connect with nature.
Tailoring Your Microdosing Experience
Intuitive microdosing allows you to decide how microdosing fits into your life.
One example of how to use it would be to consider whether a microdose would enhance or hinder your planned activities. For example, if you find microdoses improve focus and productivity, you might choose to microdose on workdays. For the same reason, you might opt out of a microdose if you are planning a more relaxed day. Physical activity might also influence your decision, as some people find microdosing enhances their performance, while others prefer to abstain.
Your social plans might also impact your microdosing choices. If you are anticipating a social gathering, your decision of whether or not to microdose will depend on factors like if you have found microdoses enhance your communication skills or decrease social anxiety.
Your daily energy levels and mood can also be valuable indicators for microdosing. If you are feeling low on energy or experiencing a challenging mood, a microdose might provide a boost. However, if you are already feeling energised and positive, you might choose to skip a microdose.
These are just a few examples, and these decisions will all be best made depending on your personal experiences and the effects you receive. The way to explore intuitive microdosing is to carefully experiment and discover what works for you.
Benefits and Drawbacks
Intuitive microdosing offers several potential benefits. It allows for a high degree of flexibility and personalization, enabling users to adapt their microdosing practice to their unique needs and experiences. This can potentially lead to more targeted effects. Another benefit of this approach is that it encourages self-awareness through a deeper connection with internal cues, and an increased awareness of external circumstances.
However, the lack of structure inherent in intuitive microdosing can also present challenges. Without a set schedule, it can be difficult to track progress and identify patterns. Additionally, relying solely on intuition may lead to inconsistent results, making it difficult to determine the optimal microdosing approach.
Who is Intuitive Microdosing for?
Intuitive microdosing is well-suited for individuals who would like a more flexible approach and have developed a solid understanding of how microdosing affects them through prior experience. This would mean having observed how it impacts their focus, creativity, mood, and energy levels in various settings, so that they are well-prepared to make informed decisions about when to microdose without following a set pattern. If varying the dosage within the microdose range, it will also be important to have experimented with different dosages.
Additionally, individuals who are familiar with the effects of microdosing in various situations and activities can make informed decisions about when to microdose based on their specific needs and goals. For example, someone who has noticed enhanced creativity while microdosing might choose to microdose on days dedicated to artistic projects. Similarly, individuals who experience increased focus and productivity may opt for microdosing on workdays.
Overall, this approach is ideal for those who prefer a flexible and self-guided microdosing experience and are comfortable with making spontaneous decisions without adhering to a strict schedule.
Choosing the Right Microdosing Protocol
Final Thoughts